Biological Sample Analysis
Analysis of oligonucleotide drugs
In recent years, oligonucleotide drugs have become the focus of research and development. They can be synthesized by solid phase synthesis instrument or liquid phase chemical methods. Therefore, it is possible to modify each single nucleotide to optimize its specificity, stability, pharmacokinetics and other aspects. IPHASE has a professional team and complete equipment to support the screening and development of oligonucleotide drugs.
The analytical methods mainly include LC-UV, LC-MS, ELISA, LC-FLD and qRT-PCR, among which, high resolution mass spectrometry (LC-TOF-MS) can be used for qualitative or quantitative analysis of unknown metabolites by full scanning and multiple ion scanning due to its high resolution, sensitivity, specificity and quality accuracy.